For Christian readers attempting to navigate the theological labyrinth that practically defies tracking as theology has stretched itself into the scientific arena. This work approaches a tough task with a biblically-based interpretation of nature, reality, rationality, and God's act in the world, taking stock of the current status of the theology and science interface and critically reviewing its weaknesses and strengths. It functions as a guide, laying a clear path for the readers to find their way out into the world of open systems.