This Element critically explores the potential relevance of God or a soul for life's meaning as discussed in recent Anglo-American philosophical literature. There have been four broad views: God or a soul is necessary for meaning in our lives; neither is necessary for it; one or both would greatly enhance the meaning in our lives; one or both would substantially detract from it. This Element familiarizes readers with all four positions, paying particular attention to the latter two, and also presents prima facie objections to them, points out gaps in research agendas and suggests argumentative strategies that merit development.