Migration is a problem of highest importance today, and likewise is its history. Italian migrants who had to leave the peninsula in the long sixteenth century because of their heterodox Protestant faith is a topic that has its deep roots in Italian Renaissance scholarship since Delio Cantimori: It became a part of a twentieth century form of Italian leyenda negra in liberal historiography. But its international dimension and Central Europe (not only Germany) as destination of that movement has often been neglected. Three different levels of connectivity are addressed: the materiality of communication (travel, printing, the diffusion of books and manuscripts); individual migrants and their biographies and networks; and the cultural transfers, discourses, and ideas migrating in one or in both directions.