In March 1199, Emperor Alexius III Angelus Comnenus sent Nicholas the physician to Genoa to negotiate privileges following the removal of a wicked leader who had harmed the community's relationship with the kingdom. The emperor expressed goodwill towards Genoa and acknowledged the community's prior misdeeds while urging them to send ambassadors for friendship discussions. Subsequent entries from June 1199 and April 1201 detail the emperor's grants of public faith to Pisan envoys and Guglielmo Cacallaro for addressing piracy issues, culminating in the transfer of properties to the Genoese in Constantinople in October 1202.