A dedicated nurse and a determined doctor-bound by past heartbreak, united by crisis, and given a second chance at love.

Dr. Phineas Mackenzie has a bold vision for bringing medical care to New Orleans's immigrant neighborhoods. But the 1905 Yellow Fever crisis threatens everything-and everyone-he holds dear. The last thing he expects is to find himself working alongside the woman who broke his heart five years ago.

Nurse Natalie Morrison returned from the Panama mission field with a plan to stay just long enough to recover her health. But as she assists with the mounting fever cases, she finds herself questioning everything she thought she knew about her calling. Working beside Phin awakens feelings she thought she'd buried, yet pursuing them would mean abandoning her missionary vows and her father's dying wish.

As they fight to save lives in a city gripped by an epidemic, Phin and Natalie discover that sometimes love requires choosing between two kinds of duty-and that God's call may lead in unexpected directions.