Artificial intelligence (AI) and the Holy Spirit intersect in a profound theological discourse that distinguishes divine power, spiritual truth, and human agency from artificial computational systems. This document explores how believers, empowered by the Holy Spirit, engage AI discerningly to expose its limitations, resist deception, and affirm God's ultimate sovereignty over all creation, including technology. It emphasizes the unique, transformative, and relational nature of the Spirit's work, contrasting it with AI's algorithmic, non-sentient operations, and highlights the spiritual challenges and prophetic implications posed by AI in contemporary and eschatological contexts