The volume focuses on the relation between Cusanus and Aristotle or the Aristotelian tradition. In recent years the attention on this topic has partially increased, but overall the scholarship results are still partial or provisional. The book thus aims at verifying more systematically how Aristotle and Aristotelianism have been received by Cusanus, in both their philosophical and theological implications, and how he approached the Aristotelian thought. In order to answer these questions, the papers are structured according to the traditional Aristotelian sciences and their reflection on Cusanus' thought. This allows to achieve some aspects of interest and originality: 1) the book provides a general, but systematic analysis of Aristotle's reception in Cusanus' thought, with some coherent results. 2) Also, it explores how a philosopher and theologian traditionally regarded as Neoplatonist approached Aristotle and his tradition (including Thomas Aquinas), what he accepted of it, what he rejected, and what he tried to overcome. 3) Finally, the volume verifies the attitude of a relevant Christian philosopher and theologian of the Humanistic age towards Aristotle.