Optimistic Ophthalmologist follows Candide, a hopeful graduate from the World's Best Medical School, whose life takes a dramatic turn after a tryst costs him his neurosurgery residency. Reassigned to ophthalmology, Candide embarks on a series of tumultuous adventures starting in Miami at the World's Best Eye Institute.

Candide's journey takes him across the globe, filled with dramatic twists: a passionate romance, a narrow escape from a catastrophic airplane crash, the challenge of mastering cataract surgery, and the dark turn of committing murder. He faces the brink of death with cannibals and, throughout it all, provides care for the sick, often with surprising results.

Accompanying him on this wild ride are characters from Voltaire's classic: the eternally optimistic Pangloss, the enigmatic Cunegonde, the resourceful Old Woman, the steadfast Cacambo, and the undying cynic Martin. These companions bring humor, wisdom, and intrigue to Candide's journey, enriching his experiences and challenging his perspectives.

Along the way, they encounter a slew of eccentric characters: the lascivious Grand Inquisitor, the overzealous Equitya Whitewash, the avaricious Milo Vanderdendur, and the incompetent duo of Drs. Ra