This penultimate book starting from Page 0 explained how we derive rigorous proofs for three famous open problems Riemann hypothesis, Polignac's and Twin prime conjectures in forward and reverse direction. The reverse engineered proofs should and must be a formality with this process furthermore providing invaluable insights into these three problems which are classified as Incompletely Predictable problems. Connection between Maths, Science, Medicine, Pharmacology, Laboratory tests, Physiology and Religion are elaborated upon.