Volume 1 of The Annotated Luther series contains writings that defined the roots of reform set in motion by Martin Luther, beginning with the Ninety-Five Theses (1517) through The Freedom of a Christian (1520). Included are treatises, letters, and sermons written from 1517 to 1520, which set the framework for key themes in all of Luthers later works. Also included are documents that reveal Luthers earliest confrontations with Rome and his defense of views and perspectives that led to his excommunication by Leo X in 1520.

These documents display a Luther grounded in late medieval theology and its peculiar issues, trained in the latest humanist methods of the Renaissance, and, most especially, showing sensitivity toward the pastoral consequences of theological positions and church practice.