Through narrative and comic panels, Hendrix chronicles Lewis and Tolkien's near-idyllic childhoods, then moves on to both men's horrific tour of the trenches of World War I to their first meeting at Oxford in 1929, and then the foreshadowing, action, and aftermath of World War II.He reveals the shared story of their friendship, in all its ups and downs, that gave them confidence to venture beyond academic concerns (fantasy wasn't considered suitable for adult reading, but the domain of children), shaped major story/theme ideas, and shifted their ideas about the potential of mythology and faith.

The Mythmakers also shows the camaraderie and the importance of the social/literary circle of friends called the Inklings, and how the friendship of these two great men fell apart and came together again.