The present volume offers the first accessible English translation and commentary on Jerome's Epistle 106, an important work of patristic biblical interpretation. In his treatise Jerome discusses different textual and exegetical options according to various Greek and Latin copies of the Psalms with input from the Hebrew. Epistle 106 provides insightful commentary on the Gallican Psalter, Jerome's translation of Origen's hexaplaric edition. Jerome's work offers a unique window into the complex textual state of the Psalter in the late fourth century and serves as an outstanding example of ancient philological scholarship on the Bible.